Born in Morbegno (Sondrio) in 1991, he graduated with honours in trombone at the Conservatoire in Como in 2009. In 2014 he got a second-level academic diploma at the Conservatoire in Aosta with the best grades and honours. As a trombonist he went on tours around the whole world under the direction of conductors like John Axelrod, Andrey Boreyko, Fabio Luisi and Riccardo Muti.
In 2010 he began the studies to become an orchestra conductor with Maestro Ennio Nicotra, taking lessons by John Axelrod, Massimiliano Caldi, Gilberto Serembe, Pietro Mianiti, Oleg Caetani and Antonio Eros Negri.
His career as conductor began in December 2011, conducting the Orchestra Antonio Vivaldi, which was created by him with composer Piergiorgio Ratti. With this Orchestra he conducts more than ten symphonic productions every year. His most ambitious project was a tour in China in January 2020, where the Orchestra performed in six Chinese cities, under the guidance of its musical director.
Some pieces by Piergiorgio Ratti, Antonio Eros Negri, Andrea Battistoni and Andrea Portera were dedicated to and performed for the first time by Lorenzo Passerini.
In 2016 he made his debut as guest conductor of the Orchestra ICO della Magna Grecia and the Orchestra Regionale Filarmonia Veneta, on the occasion of the XXVIII international opera singing contest “Iris Adami Corradetti”.
The following year he conducted the Orchestra Sinfonica di Milano Giuseppe Verdi, the Orchestra della Fondazione Arena di Verona, the Orchestra Regionale Toscana, the Romanian National Opera Orchestra, the Orchestra Sinfonica di Sanremo, the Orchestra Camerata Musica Wien, the Symphony Orchestra of the State of Mexico and the Milano Chamber Orchestra.
In the same year he was assistant conductor of Maestro Oleg Caetani at the Opera House in Helsinki, for the opera Lady Macbeth of the Mtsensk District by Shostakovich.
Lorenzo Passerini has been the artistic and musical director of the Orchestra Antonio Vivaldi since its creation. Since 2017 he has been the artistic director of the Symphonic Season of the Teatro Sociale in Sondrio and of the Association “Amici della Musica” in Sondalo.
Since 2015 he has collaborated with Maestro Nicola Luisotti for opera productions in the most famous theaters in Europe: Royal Opera House in London, Teatro Real in Madrid and Teatro alla Scala in Milan.
In Autumn 2018 he was his assistant in the production of Puccini’s Turandot at the Teatro Real in Madrid. In the same year he conducted again the Orchestra della Fondazione Arena di Verona, the Orchestra di Padova e del Veneto, the Orchestra Sinfonica Metropolitana di Bari and the DITTO Orchestra on the occasion of the tour in South Korea with soprano Sumi Jo.
In 2019 he conducted the State Symphony Orchestra "Novaya Rossiya" at Moscow's Tchaikovsky Hall with soprano Nadine Sierra, the Ravello Festival's Concerto all’alba with the Salerno Symphony Orchestra, Tosca at the Teatro Regio in Turin replacing Daniel Oren, Carl Orff’s Carmina Burana at the National Opera in Warsaw and a gala concert with tenor Francesco Demuro at the Teatro dell’Opera in Sassari.
In 2020 he worked at the Sydney Opera House conducting Charles Gounod’s Faust, at the Teatro Real in Madrid with the opera Un ballo in maschera, where he shared the stage with Nicola Luisotti, in Parma with the Orchestra Filarmonica Toscanini and in Genua with the “Carlo Felice” Theatre Orchestra.
In 2021 he conducted the Orchestra Sinfonica Siciliana, made his debut at the Theatre of Las Palmas in Gran Canaria (with Rossini's La Cenerentola) and he conducted Aida at the Sydney Opera House. Soon he will be at the Zagabria National Theatre (with Puccini's La Rondine), at the Theatre de Champes Elysée in Paris, in a gala with soprano Pretty Yende.
In 2022 he will conduct Puccini's La Bohème at the Sydney Opera House, make his debut at the Teatro San Carlo di Napoli (Bellini's Sonnambula), the Frankfurt Opera House (Giordano's Fedora), the Opéra Royal de Wallonie (Gala with soprano Nadine Sierra), the Konzerthaus Dortmund (Gala with soprano Nadine Sierra and tenor Xabier Anduaga), the Essen Opera House (Rossini's Barbiere), the Rossini Opera Festival in Pesaro (Gala with Luca Pisaroni), the Turku Festival in Finland (Gala with soprano Nadine Sierra) and the Théâtre du Capitole in Toulouse (Puccini's La Bohème).